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Bibliography on: Classical Genetics: Mutation

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ESP: PubMed Auto Bibliography 22 Jan 2021 at 01:35 Created: 

Classical Genetics: Mutation

Wikipedia: We now know that, in biology, a mutation is the process that produces heritable change via the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements. Mutations result from errors during DNA replication or other types of damage to DNA (such as may be caused by exposure to radiation or carcinogens), which then may undergo error-prone repair, or cause an error during other forms of repair, or else may cause an error during replication. Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. In the early days of classical genetics, work to characterize, model, and understand the phenomenology of mutation were critically important for developing the foundations of modern molecular genetics.

Created with PubMed® Query: 1859:1953[PDAT] AND (mutation OR mutant OR mutagen) NOT pmcbook NOT ispreviousversion

Citations The Papers (from PubMed®)

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RevDate: 2019-06-18
CmpDate: 2003-05-01

ROSIN A, F DOLJANSKI (1953)

Effect of hydroquinone on mitosis.

Nature, 172(4390):1151.

RevDate: 2020-09-30
CmpDate: 2003-05-01

CARLSON AJ, NR BREWER (1953)

Toxicity studies on hydroquinone.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 84(3):684-688.

RevDate: 2018-12-01
CmpDate: 2003-05-01

MORRIS GE (1953)

Synthetic rubbers; their chemistry and dermatological aspects.

A.M.A. archives of industrial hygiene and occupational medicine, 8(6):540-546.

RevDate: 2018-12-01
CmpDate: 2003-05-01

MUHLEMANN H (1953)

[Anthraquinone and anthraquinone glycosides; the synthesis of Chrysazinhydroquinone-1-glycoside and chrysazin-9-anthrone-1-glycoside].

Pharmaceutica acta Helvetiae, 28(11):313-319.

RevDate: 2018-12-01
CmpDate: 2003-05-01

FORMAN L (1953)

A note on the depigmentary properties of monobenzylether of hydroquinone.

The British journal of dermatology, 65(11):406-409.

RevDate: 2018-12-01
CmpDate: 2003-05-01

GIUGIARO A, D CASTELLI (1953)

[Trimethyl (methylphenyldodecyl) ammonium methyl sulfate in preoperative antisepsis].

Minerva chirurgica, 8(18):716-722.

RevDate: 2019-06-29
CmpDate: 2003-05-01

DENTON CA, WL KELLOGG (1953)

The vitamin B12 activity of eggs and some materials as affected by extraction in the presence of sodium cyanide or sodium bisulfite.

Archives of biochemistry and biophysics, 46(1):105-109.

RevDate: 2018-12-01
CmpDate: 2003-05-01

DEUFEL J, H GANSHIRT (1953)

[Studies on the effect of aristolochic acid on bacteria and cell division of Vicia faba L].

Die Pharmazie, 8(8):679-682.

RevDate: 2019-08-27
CmpDate: 2003-05-01

MARKS MM (1953)

Clinical re-evaluation of dorbane in the treatment of functional constipation.

The American journal of digestive diseases, 20(8):240-242.

RevDate: 2018-12-01
CmpDate: 2003-05-01

PARMENTIER R, G ASTALDI (1953)

[First research on the effects of hydroquinone on proliferation of human bone marrow cells cultivated in vitro].

Bollettino della Societa italiana di biologia sperimentale, 29(7):1315-1317.

RevDate: 2018-12-01
CmpDate: 2003-05-01

PARMENTIER R, P DUSTIN (Jr) (1953)

[On the mechanism of the mitotic abnormalities induced by hydroquinone in animal tissues].

Revue belge de pathologie et de medecine experimentale, 23(1):20-30.

RevDate: 2018-12-01
CmpDate: 2003-05-01

GRIANTI V, E BARTALINI (1953)

[The use of lipotropic substances, complex B and liver extracts in some cases of industrial liver disease].

Rassegna di medicina industriale e di igiene del lavoro, 22(4-5):220-232.

RevDate: 2018-12-01
CmpDate: 2003-05-01

GANSHIRT H (1953)

[Isolation of aristolochic acid from various Aristolochiaceae and its quantitative determination].

Die Pharmazie, 8(7):584-592.

RevDate: 2018-12-01
CmpDate: 2003-05-01

HOFFMANN CR (1953)

Indications for the use of diphenmethanil methyl sulfate (prantal) in the treatment of peptic ulcer.

American practitioner and digest of treatment, 4(7):464-468.

RevDate: 2018-12-01
CmpDate: 2003-05-01

PARMENTIER R (1953)

[Fusorial action of hydroquinone in the rabbit].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 147(9-10):935-937.

RevDate: 2019-06-18
CmpDate: 2003-05-01

VLITOS AJ, KING LF, LJ AUDUS (1953)

Fate of sodium 2, 4-dichloro-phenoxy-ethyl-sulphate in the soil.

Nature, 171(4351):523-524.

RevDate: 2018-12-01
CmpDate: 2003-05-01

VIVINO AE, G RITTER (1953)

Treatment of dysmenorrhea with a dioxolane.

The Medical annals of the District of Columbia, 22(3):117-8; passim.

RevDate: 2019-06-28
CmpDate: 2003-05-01

KEATS AS, HK BEECHER (1953)

The analgesic effectiveness of morphine solutions containing sodium bisulfite.

Anesthesiology, 14(2):140-142.

RevDate: 2019-11-07
CmpDate: 2003-05-01

BIRD MJ, OG FAHMY (1953)

Cytogenetic analysis of the action of carcinogens and tumour inhibitors in Drosophila melanogaster. I. 1:2, 3:4-diepoxybutane.

Proceedings of the Royal Society of London. Series B, Biological sciences, 140(901):556-578.

RevDate: 2018-12-01
CmpDate: 2003-05-01

MILOSEVIC MP, DB TODOROVIC (1953)

Influence of sodium bisulphite on the absorption rate of acetylcholine and of 1-noradrenaline.

Acta medica Iugoslavica, 7(3):197-203.

RevDate: 2018-12-01
CmpDate: 2003-05-01

BOREUS LO, F SANDBERG (1953)

The analgesic action of n-acetyl p-aminophenol and its combination with some other substances.

Acta physiologica Scandinavica, 28(2-3):266-271.

RevDate: 2018-12-01
CmpDate: 2003-05-01

BOREUS LO, F SANDBERG (1953)

A comparison of some pharmacological effects of acetophenetidin and N-acetyl p-aminophenol.

Acta physiologica Scandinavica, 28(2-3):261-265.

RevDate: 2019-06-19
CmpDate: 2003-05-01

WASE AW, ALLISON JB, JF MIGLIARESE (1952)

The effect of 2-aminofluorene on the utilization of S35 DL-methionine.

Science (New York, N.Y.), 116(3020):536-537.

RevDate: 2019-06-29
CmpDate: 2003-05-01

WITKOP B, S GOODWIN (1952)

Significance and rearrangements of quinol models of tyrosine metabolites.

Experientia, 8(10):377-379.

RevDate: 2018-12-01
CmpDate: 2003-05-01

STONE CA, KOMRAD EL, ER LOEW (1952)

Adrenergic blocking properties of N-ethyl-N-(2-chloroethyl)-9-fluorenamine hydrochloride.

Archives internationales de pharmacodynamie et de therapie, 92(1):7-12.

RevDate: 2019-07-03
CmpDate: 2003-05-01

HUNTER AR (1952)

Strychnine dimethyl sulphate.

Anaesthesia, 7(4):206-210.

RevDate: 2018-12-01
CmpDate: 2003-05-01

ALLISON JB, AW WASE (1952)

The effects of dietary riboflavin and pantothenic acid on the metabolism of 2-aminofluorene.

Cancer research, 12(9):647-650.

RevDate: 2018-12-01
CmpDate: 2004-02-15

GUTMANN HR, KIELY GE, M KLEIN (1952)

The metabolism of 2-aminofluorene in the rat.

Cancer research, 12(5):350-355.

RevDate: 2020-09-30
CmpDate: 2004-02-15

KELLY KH, BIERMAN HR, MB SHIMKIN (1952)

Negative effects of oral monobenzyl ether of hydroquinone in malignant melanoma in man.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 79(4):589-590.

RevDate: 2019-05-16
CmpDate: 2004-02-15

BIELSCHOWSKY F, M BIELSCHOWSKY (1952)

The carcinogenic activity of N-mono-methyl- and N-dimethyl-2-aminofluorene.

British journal of cancer, 6(1):89-92.

RevDate: 2019-09-06
CmpDate: 2004-02-15

SVEDRES EV, GL JENKINS (1952)

Aminoacyl derivatives of 2-aminofluorene and 2,2'-diamino-9,9'-spirobifluorene.

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 41(2:1):68-71.

RevDate: 2019-05-01
CmpDate: 2004-02-15

ROBINSON D, SMITH JN, RT WILLIAMS (1951)

Studies in detoxication. 40. The metabolism of nitrobenzene in the rabbit; o-, m- and p-nitrophenols, o-, m- and p-aminophenols and 4-nitrocatechol as metabolites of nitrobenzene.

The Biochemical journal, 50(2):228-235.

RevDate: 2020-09-30
CmpDate: 2004-02-15

MARGOLIN S, DOYLE M, GIBLIN J, et al (1951)

Pharmacological properties of a new parasympathetic blocking agent, N,N dimethyl 4-piperidylidene 1,1 diphenylmethane methyl sulfate (Prantal).

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 78(2):576-580.

RevDate: 2018-12-01
CmpDate: 2004-02-15

FISHER AA (1951)

Treatment of chloasma with monobenzyl ether of hydroquinone.

A.M.A. archives of dermatology and syphilology, 64(5):645-646.

RevDate: 2019-05-16
CmpDate: 2004-02-15

RAY FE, JH PETERS (1951)

Secretion by the stomach of potential carcinogens derived from 2-aminofluorene.

British journal of cancer, 5(3):364-369.

RevDate: 2018-12-01
CmpDate: 2004-02-15

MUHLEMANN H (1951)

[Anthraquinone and anthraquinonglycosides; nuclear synthesis of frangulaemodin and of a chrysophanic acid isomer, (1,6-dioxy-3-methylanthraquinone)].

Pharmaceutica acta Helvetiae, 26(6):195-203.

RevDate: 2019-06-18
CmpDate: 2004-02-15

LEA AJ (1951)

Effect of hydroquinone monobenzyl ether on melanin formation in vitro.

Nature, 167(4257):906.

RevDate: 2020-09-30
CmpDate: 2004-02-15

ROBERTSON C, LASH J, CORNBLEET T, et al (1951)

Effect of sodium bisulfite and rutin on action of epinephrine; the "bisulfite phenomenon" in man.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 77(1):164-167.

RevDate: 2019-11-08
CmpDate: 2004-02-15

ORR RJ, HL WILLIAMS (1951)

The compositional heterogeneity of butadiene-styrene copolymers synthesized at 18 degrees C. in emulsion.

Canadian journal of chemistry, 29(3):270-283.

RevDate: 2019-11-08
CmpDate: 2004-02-15

EMBREE WH, MITCHELL JM, HL WILLIAMS (1951)

Compositional heterogeneity of butadiene-acrylonitrile copolymers prepared in emulsion at 5 degrees C.

Canadian journal of chemistry, 29(3):253-269.

RevDate: 2018-12-01
CmpDate: 2004-02-15

ISAGULIANTS VI, GT ESAIAN (1951)

[Synthesis of arylbutadienes].

Doklady Akademii nauk SSSR, 76(4):531-534.

RevDate: 2018-12-01
CmpDate: 2004-02-15

BALO J, VANDOR F, P REINMAN (1951)

[Effect of hydroquinone on the growth of transmissible mice cancer].

Kiserletes orvostudomany, 3(3):191-194.

RevDate: 2018-12-01
CmpDate: 2004-02-15

HOPPE JO, FC GOBLE (1951)

The intravenous toxicity of sodium bisulfite.

The Journal of pharmacology and experimental therapeutics, 101(1):101-106.

RevDate: 2018-12-01
CmpDate: 2004-02-15

HERBUT PA, KRAEMER WH, J JACKSEN (1951)

The effect of hepbisul (heptyl aldehyde-sodium bisulfite addition compound) and thyroxin on Walker rat carcinoma 256.

The American journal of pathology, 27(1):59-83.

RevDate: 2019-06-18
CmpDate: 2004-02-15

CUNNINGHAM KG, MANSON W, SPRING FS, et al (1950)

Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link.

Nature, 166(4231):949.

RevDate: 2018-12-01
CmpDate: 2004-09-30

MICKLER EE, LW DIGGS (1950)

The detection of the sickle cell trait; a comparison of the sealed moist preparation using capillary blood collected during venous stasis and the sodium bisulfite method.

American journal of clinical pathology, 20(9):861-864.

RevDate: 2018-12-01
CmpDate: 2004-02-15

BOLIS L (1950)

[Blastomogenic function of 2-acetylaminofluorene and 2-amino-fluorene].

Tumori, 24(5):244-250.

RevDate: 2018-12-01
CmpDate: 2004-09-30

POLLOCK JH (1950)

Hyperpigmentation improved by treatment with monobenzyl ether of hydroquinone.

Archives of dermatology and syphilology, 61(5):873-875.

RevDate: 2018-12-01
CmpDate: 2004-09-30

GRUBER CM, DE BERADINIS CT, SHIELDS HL, et al (1950)

A pharmacologic and toxicologic study of heptyl aldehyde sodium bisulfite (hepbisul).

The Journal of pharmacology and experimental therapeutics, 98(3):274-285.

RevDate: 2018-12-01
CmpDate: 2004-09-30

TREON JF, H SIGMON (1949)

The toxicity of methyl and ethyl acrylate.

The Journal of industrial hygiene and toxicology, 31(6):317-326.

RevDate: 2018-12-01
CmpDate: 2004-09-30

POZZANI UC, WEIL CS, CP CARPENTER (1949)

Subacute vapor toxicity and range-finding data for ethyl acrylate.

The Journal of industrial hygiene and toxicology, 31(6):311-316.

RevDate: 2018-12-01
CmpDate: 2004-09-30

BROWN BB, HW WERNER (1949)

The parasympathetic depressant and antihistaminic action of substituted 1,3-dioxolanes.

The Journal of pharmacology and experimental therapeutics, 97(2):157-170.

RevDate: 2018-12-01
CmpDate: 2007-12-27

BERGER FM (1949)

The pharmacological properties of 2-methyl,2-n-amyl-4-hydroxymethyl-1,3-dioxolane (glyketal) a new blocking agent of interneurons.

The Journal of pharmacology and experimental therapeutics, 96(3):213-223.

RevDate: 2019-05-09
CmpDate: 2007-12-27

SOLLMANN T (1949)

Correlation of the aquarium goldfish toxicities of some phenols, quinones, and other benzene derivatives with their inhibition of autooxidative reactions.

The Journal of general physiology, 32(6):671-679.

Hydroquinone when added to the aquarium water was found to be about a hundred times more toxic than phenol, to goldfish (and to Daphnia magna), but is only about twice as toxic when injected into fish or mammals. Tertiarybutyl catechol shows a similar high toxicity in the aquarium, while the toxicity of catechol, resorcinol, and pyrogallol approaches more closely that of phenol. As the substances of high aquarium toxicity are known to inhibit many oxidative and polymerizing autocatalytic "chain reactions," rank correlations were tabulated between the recorded inhibitory potency of various substances in these processes, and their aquarium toxicity for goldfish. The correlation between aquarium fish toxicity and electric oxidation potential (P 0.09) is more than suggestive, and becomes still more so if explainable discrepancies are excluded. Antioxidant fat stabilizers show suggestive correlation with fish toxicity (0.20), and better with electric oxidation potential (0.10). The photographic reduction potential gives suggestive correlation with fish toxicity (0.20) and somewhat better with the oxidation potential (0.15). The gasoline induction period correlation is more than suggestive with the oxidation potential (0.099), but rather poor for fish toxicity (0.265). The rubber anti-aging potency gives only poor correlation (0.39) with fish toxicity. The reasons for these divergencies are not clear; they may perhaps be connected with the solvent properties of the substrate. As an example, Lea (p. 175) cites that 0.01 per cent of maleic acid prevents rancidity of fats, but is rendered ineffective by the presence of water. Taken by themselves, no one of the P values is entirely convincing of the relationships stressed in this paper. However, the consistent finding of relatively small values of P lends considerable weight to the hypothesis that these chemicals act in a related manner; and that the chemical activity of a substance may furnish useful suggestions of its biologic potency, perhaps more so than the chemical constitution as such. The aquarium toxicity, for goldfish is a convenient means of classifying the biologic potency.

RevDate: 2019-09-07
CmpDate: 2007-12-27

JAROWSKI CI, MK McPHAIL (1949)

The antipyretic action of some derivatives of salicylic acid, p-aminophenol, and dihydropyrazolon.

Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 38(6):349-352.

RevDate: 2019-11-10
CmpDate: 2007-12-27

BERNSTEIN ET, PM SACHS (1949)

Pigmentary disturbance following exposure to monobenzyl ether of hydroquinone.

Archives of dermatology and syphilology, 59(5):542-548.

RevDate: 2019-06-18
CmpDate: 2008-01-28

ABDEL FATTAH ALY ISMAIL (1949)

A quinonoid structure for hydroquinone pyridinium salts of organic acids.

Nature, 163(4145):565.

RevDate: 2019-06-18
CmpDate: 2008-01-21

CARVER JH, GK WHITE (1949)

Methylene bromide as a quenching agent in Geiger-Müller counters.

Nature, 163(4144):526.

RevDate: 2018-12-01
CmpDate: 2007-12-27

HODGE HC, JH STERNER (1949)

Short-term toxicity tests on the mono and di methyl ethers of hydroquinone.

The Journal of industrial hygiene and toxicology, 31(2):79-92.

RevDate: 2020-09-30
CmpDate: 2007-12-27

LEIN J, PS LEIN (1949)

Stabilization of the thromboplastic lipid by hydroquinone.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 70(3):446-448.

RevDate: 2019-07-08
CmpDate: 2008-01-21

WINTERSTEINER O, A KLINGSBERG (1949)

The partial methylation of methyl beta-D-xylopyranoside with methyl sulfate.

Journal of the American Chemical Society, 71(3):939-942.

RevDate: 2018-12-01
CmpDate: 2008-01-22

GARTON GA, RT WILLIAMS (1949)

Studies in detoxication; the fates of quinol and resorcinol in the rabbit in relation to the metabolism of benzene.

The Biochemical journal, 44(2):234-238.

RevDate: 2020-10-05
CmpDate: 2007-12-27

CORTI UA (1949)

Results of the methylation of tyrosine with dimethyl sulfate and some derivatives of N-methyltyramine.

Helvetica chimica acta, 32(3):681-686.

RevDate: 2018-12-01
CmpDate: 2007-12-27

PORTEOUS JW, RT WILLIAMS (1949)

Studies in detoxication; the metabolism of benzene; the isolation of phenol, catechol, quinol and hydroxyquinol from ethereal sulphate fraction of the urine of rabbits receiving benzene orally.

The Biochemical journal, 44(1):56-61.

RevDate: 2018-12-01
CmpDate: 2007-12-27

PORTEOUS JW, RT WILLIAMS (1949)

Studies in detoxication; the metabolism of benzene; the determination of phenol in urine with 2:6-dichloroquinonechloroimide; the excretion of phenol, glucuronic acid and ethereal sulphate by rabbits receiving benzene and phenol; observations on the determination of catechol, quinol and muconic acid in urine.

The Biochemical journal, 44(1):46-55.

RevDate: 2019-05-01
CmpDate: 2004-09-30

TARNOKY AL, VA BREWS (1949)

Determination of p-aminosalicylic acid as m-aminophenol.

The Biochemical journal, 45(4):508-511.

RevDate: 2018-12-01
CmpDate: 2007-12-27

RICHARDS RK, KE KUETER (1948)

Antagonism of rutin to capillary effects of sodium bisulfite and procaine.

The Journal of pharmacology and experimental therapeutics, 94(4):372-381.

RevDate: 2018-12-01
CmpDate: 2010-07-02

Berger FM, Boekelheide V, DS Tarbell (1948)

The Pharmacological Properties of Some 2-Substituted-4-hydroxymethyl-1,3-dioxolanes.

Science (New York, N.Y.), 108(2812):561-562.

RevDate: 2019-07-08
CmpDate: 2008-01-22

SCHULZE WA, WW CROUCH (1948)

Composition of butadiene-styrene copolymers from sodium-catalyzed polymerization.

Journal of the American Chemical Society, 70(11):3891-3893.

RevDate: 2019-07-08
CmpDate: 2008-01-22

MARVEL CS, JL WILLIAMS (1948)

2-Alkyl-1,3-butadienes.

Journal of the American Chemical Society, 70(11):3842-3846.

RevDate: 2019-07-08
CmpDate: 2008-01-22

McELVAIN SM, MJ CURRY (1948)

Ketene acetals; 2-methylene-1,3-dioxolanes and 1,3-dioxanes.

Journal of the American Chemical Society, 70(11):3781-3786.

RevDate: 2019-07-08
CmpDate: 2008-10-20

CROWELL TI, LP HAMMETT (1948)

Kinetics of the reactions of thiosulfate ion with ethyl, propyl and isopropyl bromides.

Journal of the American Chemical Society, 70(10):3444-3450.

RevDate: 2018-12-01
CmpDate: 2007-12-27

LORA-TAMAYO M, JL LEON (1948)

The condensation of 2 :3-dimethyl-l :3-butadiene and p-benzo-quinone.

Journal of the Chemical Society, 3:1499-1501.

RevDate: 2018-12-01
CmpDate: 2008-10-16

FLINN FB, BB BRODIE (1948)

The effect on the pain threshold of N-acetyl p-aminophenol, a product derived in the body from acetanilide.

The Journal of pharmacology and experimental therapeutics, 94(1):76.

RevDate: 2018-12-01
CmpDate: 2008-10-16

BRODIE BB, J AXELROD (1948)

The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-amino-phenol, free and total conjugated, in biological fluids and tissues.

The Journal of pharmacology and experimental therapeutics, 94(1):22-28.

RevDate: 2019-05-16
CmpDate: 2007-12-27

KIRBY AH (1948)

The action of 2-aminofluorene in three pure strains of mice.

British journal of cancer, 2(3):294-300.

RevDate: 2018-12-01
CmpDate: 2008-10-20

KARCZMAR AG (1948)

Influence of methyl bis amine, hydroquinone and thyroxin on regeneration in urodele larvae.

The Anatomical record, 101(4):712.

RevDate: 2019-11-11
CmpDate: 2008-10-16

PALIN DE, HM POWELL (1948)

The structure of molecular compounds; the clathrate compound of quinol and methanol.

Journal of the Chemical Society, 2:571-574.

RevDate: 2019-06-18
CmpDate: 2008-10-20

PARMENTIER R, P DUSTIN (Jr) (1948)

Early effects of hydroquinone on mitosis.

Nature, 161(4092):527.

RevDate: 2020-10-05
CmpDate: 2008-10-16

LACASSAGNE A, NP BUU-HOI (1948)

Contribution to the study of the carcinogenic power of 2-aminofluorene.

Comptes rendus des seances de la Societe de biologie et de ses filiales, 142(7-8):481-483.

RevDate: 2019-05-09
CmpDate: 2008-10-16

MILLER JA, EC MILLER (1948)

The carcinogenicity of certain derivatives of p-dimethylaminozobenz in the rat.

The Journal of experimental medicine, 87(2):139-156.

1. Eighteen known or possible metabolites of the hepatic carcinogen 4- (or p-) dimethylaminoazobenzene were tested for carcinogenic activity in the rat. Of these compounds only 4-monomethylaminoazobenzene, a known metabolite, proved to be active. Eight compounds, which appear to be metabolites of the dye, were inactive; these included 4-aminoazobenzene, 4'-hydroxy-4-monomethylaminoazobenzene, 4'-hydroxy-4-aminoazobenzene, N-methyl-p-phenylenediamine, p-phenylenediamine, aniline, p-aminophenol, and o-aminophenol. Nine compounds which may possibly be metabolites also were inactive; these compounds were 4'-hydroxy-, 3'-hydroxy-, and 2'-hydroxy-4-dimethylaminoazobenzene, 4-formylaminoazobenzene, 4-hydroxyazobenzene, 2, 4'-diamino-5-dimethylaminodiphenyl, 3-dimethylaminocarbazole, N,N-dimethyl-p-phenylenediamine, and p-hydroquinone. A mixture of 9 known and possible metabolites was also found to be inactive. These data indicate that the primary carcinogen operative in tumor formation by 4-dimethylaminoazobenzene is probably an azo dye closely related to the parent carcinogen. This conclusion is supported by recent work from this laboratory which indicates that the primary carcinogen consists of either or both of the protein-bound dyes found in the liver, i.e. 4-monomethylaminoazobenzene and an unidentified polar aminoazo dye, and that the formation of bound dye constitutes one of the first steps in this carcinogenic process. 2. The carcinogenic activities of 19 other compounds related to 4-dimethyl-aminoazobenzene were tested to obtain more information on the structural features needed for a 4-aminoazo dye to possess strong activity in the rat. 3'-Methyl-4-monomethylaminoazobenzene and the corresponding dimethylamino derivative were nearly twice as active and 4-ethylmethylaminoazobenzene had the same activity as 4-dimethylaminoazobenzene. As tested 3'-nitro- and 3'-chloro-4-dimethylaminoazobenzene both had about the same activity as 4-dimethylaminoazobenzene; however, since the 3'-nitro derivative was incompletely absorbed its real activity appears to be about 1(1/2) times that of 4-dimethylaminoazobenzene. 2'-Nitro- and 2'-chloro-4-dimethylaminoazobenzene were about one-half to one-third as active and 4'-chloro-4-dimethylaminoazobenzene was approximately one-fourth as active as the parent dye. 3'-Ethoxy-4-dimethylaminoazobenzene and 3-methyl-4-monomethylaminoazobenzene exhibited only slight carcinogenic activity. The following compounds proved inactive: the benzamide of N,N-dimethyl-p-phenylenediamine; the diethyl, monoethyl, benzylmethyl, beta-hydroxyethylmethyl, and formyl derivatives of 4-aminoazobenzene on the amino group; and the 3-methyl, 3', 5'-dimethyl, 2',5'-dimethyl, and 2',4'-dimethyl derivatives of 4-dimethylaminoazobenzene. From the available data two conditions appear to be essential if a dye is to possess high activity: (1) at least one methyl group must be attached to the amino group together with the proper second substituent, and (2) the rings must bear either no substituents or carry only certain substituents, preferably in the 3' position. 3. The data on the carcinogenicity of the 2'-, 3'-, or 4'-methyl, chloro, and nitro derivatives of 4-dimethylaminoazobenzene show that the position of these groups determines the carcinogenicity of these compounds to a greater extent than does the type of group. The activity relationship was 3' > 2' > 4'. 4. Primary, secondary, and tertiary aminoazo dyes were determined in the livers and blood of rats fed aminoazo dyes which differed in the substituents on the amino group. The data show that deethylation of 4-diethyl-, 4-monoethyl-, and 4-ethylmethylaminoazobenzene occurs in vivo just as 4-dimethyl- and 4-monomethylaminoazobenzene are demethylated in vivo. However, 4-benzylmethylaminoazobenzene and 4-beta-hydroxyethylmethylaminoazobenzene were dealkylated only slightly under similar conditions. 5. The following new compounds are described: 4-ethylmethyl-, 4-monoethyl-, 4-benzylmethyl-, and 4-beta-hydroxyethylmethylaminoazobenzene; 4'-hydroxy-, 3-methyl-, and 3'-methyl-4-monomethylaminoazobenzene; 2'-hydroxy-, 3'-hydroxy, 3-methyl-, 3'-ethoxy-, 3', 5'-dimethyl-, 2', 5'-dimethyl-, and 2',4'-dimethyl-4-dimethylaminoazobenzene.

RevDate: 2019-06-18
CmpDate: 2008-10-20

POWELL HM, P RIESZ (1948)

Beta-quinol; an example of the firm union of molecules without the formation of chemical bonds between them.

Nature, 161(4080):52.

RevDate: 2020-10-05
CmpDate: 2008-01-28

AHUJA (1948)

Occupational eye damage to workers in hydroquinone factories.

Klinische Monatsblatter fur Augenheilkunde und fur augenarztliche Fortbildung, 113(2):177.

RevDate: 2019-11-11
CmpDate: 2008-10-16

COGAN DG, WM GRANT (1947)

Corneal and conjunctival pigmentation among workers in hydroquinone.

Archives of ophthalmology (Chicago, Ill. : 1929), 38(6):847.

RevDate: 2019-11-11
CmpDate: 2008-10-16

ANDERSON B (1947)

Corneal and conjunctival pigmentation among workers engaged in manufacture of hydroquinone.

Archives of ophthalmology (Chicago, Ill. : 1929), 38(6):812-826.

RevDate: 2018-12-01
CmpDate: 2010-03-18

RAAB C, S GROSZ (1947)

Conjunctivitis in exposure to dimethyl-sulphate.

The British journal of ophthalmology, 31(8):509.

RevDate: 2019-06-18
CmpDate: 2010-03-29

MORELLI E, G MISLER (1947)

Action of 2-aminofluorene on moulds.

Nature, 160(4053):21.

RevDate: 2018-12-01
CmpDate: 2010-03-18

GREENBERG LA, D LESTER (1947)

The metabolic fate of acetanilid and other aniline derivatives; the role of p-aminophenol in the production of methemoglobinemia after acetanilid.

The Journal of pharmacology and experimental therapeutics, 90(2):150-153.

RevDate: 2019-05-01
CmpDate: 2008-01-11

Stern HJ (1947)

CONJUNCTIVITIS DUE TO EXPOSURE TO DIMETHYL-SULFATE.

The British journal of ophthalmology, 31(6):373-375.

RevDate: 2018-12-01
CmpDate: 2010-03-18

CASTRO BARRETTO (1947)

[Functional and therapeutic synergy of complex B].

Resenha clinico-cientifica, 16(5):190-192.

RevDate: 2019-11-11
CmpDate: 2010-03-18

JANZ GJ (1947)

Concerning the theoretical aspects of the reaction of cyanogen and 1,3-butadiene.

Canadian journal of research, 25(3):331.

RevDate: 2019-11-11
CmpDate: 2010-03-18

JANZ GJ, ASCAH RG, AG KEENAN (1947)

The reaction of cyanogen with 1,3-butadiene.

Canadian journal of research, 25(3):272-282.

RevDate: 2018-12-01
CmpDate: 2010-03-29

DREIZEN S, AW MANN (1947)

The influence of sodium bisulphite on acid production in saliva.

Journal of dental research, 26(2):93-97.

RevDate: 2020-10-05
CmpDate: 2010-03-18

DHERE C, L LASZT (1947)

Fluorescence reactions of some steroids (adrenal and sex hormones) with neutral methyl sulfate.

Comptes rendus hebdomadaires des seances de l'Academie des sciences, 224(9):681-683.

RevDate: 2018-12-01
CmpDate: 2010-03-18

HARRIS PN (1947)

Production of tumors in rats by 2-aminofluorene and 2-acetylaminofluorene; failure of liver extract and of dietary protein level to influence liver tumor production.

Cancer research, 7(2):88-94.

RevDate: 2019-11-11
CmpDate: 2010-03-29

MARION L, CG FARMILO (1947)

Note on the preparation of 1-methoxy-1,3-butadiene.

Canadian journal of research, 25(1):118-120.

RevDate: 2020-10-05
CmpDate: 2008-10-16

BOYMOND P, W JADASSOHN (1947)

About chrysarobin.

Dermatologica, 94(4):228-230.

RevDate: 2019-07-08
CmpDate: 2010-03-29

KAUFMANN S, ROSENKRANZ G, J LOPEZ (1946)

Halogenated derivatives of methyleugenol; 6-bromomethyleugenol glycol and 6-bromohomover atraldehyde.

Journal of the American Chemical Society, 68(12):2733.

RevDate: 2019-07-10
CmpDate: 2010-03-29

STAHMANN MA, C GOLUMBIC (1946)

Chemical reactions of mustard gas and related compounds; the chemistry of bis(beta-chloroethyl)-sulfone, divinyl sulfone and divinyl sulfoxide.

The Journal of organic chemistry, 11(6):719-735.

RevDate: 2018-12-01
CmpDate: 2010-10-28

DEY BB, GOVINDACHARI TR, SC RAJAGOPALAN (1946)

Electrolytic reduction of nitro compounds; the electrolytic reduction of nitrobenzene to para aminophenol.

Journal. Council for Scientific and Industrial Research (Australia), 4:574-581.

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